When a group of the most dangerous and notorious prisoners in the U.S. penal system are tranferred to a new super-maximum security facility, parolle Cameron Poe hitches a ride on their flight only to find himself embroiled in a meticulously planned mid-air hijacking masterminded by Cyrus "The Virus" Grissom. On the ground, U.S. Marshal Vince Larkin faces impossible odds as he tries to avert the takeover and, at the same time, keep his overzealous superiors from blowing the aircraft and its passengers into oblivion.